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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NAD
supplement:
Resveratrol
Research Papers that Mention the Interaction
“In this context, resveratrol activates SIRT1 (1) by directly binding to SIRT1; and (2) by increasing NAD+ levels by upregulating the salvage pathway through Nampt activation, an effect mediated by AMPK.”
Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application“Results: Resveratrol increases the mitochondrial NAD+ level by direct stimulation of complex I, leading to a SIRT3-dependent increase in substrate supplies.”
“In addition, resveratrol strongly stimulates SIRT1 deacetylase activity in a dose-dependent manner by increasing its binding affinity to both the acetylated substrate and NAD+.”
“OBJECTIVE Resveratrol RSV ) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease.”
Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.“ Resveratrol and fisetin (sirtuin activators) potentiated NAD+ loss and Zn2+ neurotoxicities.”
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