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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NAD
Research Papers that Mention the Interaction
“Addition of 10(-5) M NAD to the perfusate of isolated perfused rabbit proximal straight tubules inhibited lumen-to-bath P flux by approximately 50%.”
Nucleotide inhibition of phosphate transport in the renal proximal tubule.“ NAD+ at 0.16 mM stimulates the initiation step of the protein synthetic process in lysed rabbit reticulocytes.”
“It is concluded that this enzyme has two quaternary conformations and that the change from the quaternary conformation of the apoenzyme to the quaternary … the yeast enzyme the second NAD molecule has a higher binding affinity than the first and that the resistance of the yeast and rabbit … NAD ….”
“The free energy of activation for the conversion of tetramer into dimer for the rabbit enzyme (R4 leads to 2R2) is increased by at least 12kJ/mol in the presence of NAD+.”
“But whereas the binding of NAD to the yeast enzyme (Y4) at 40° C is considered3,… requires highly cooperative structural transitions of the subunits within a given enzyme molecule, the binding of NAD … rabbit GPD (R4) shows a negative cooperativity in that … for NAD of the remaining unoccupied sites5.”
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