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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“2-Chloro-1,4-naphtoquinone-quercetin also showed potent inhibition against SIRT2, with an IC50 value of 14 μM. Diquercetin increased the Km value of NAD+ , whereas 2-chloro-1,4-naphthoquinone-quercetin increased the Km value of the acetylated substrate.”
“Overall, the results of in vitro studies and molecular modeling indicate that diquercetin competes with nicotinamide adenine dinucleotide (NAD+), whereas 2-chloro-1,4-naphthoquinone-quercetin competes with the acetylated substrate in the catalytic site of SIRT6.”
Quercetin based derivatives as sirtuin inhibitors.“The authors reported that quercetin in MCAO-induced ischemia modulated the expression of the enzymes isocitrate dehydrogenase [ NAD+ ] (which is present in two isoforms, EC.”
“The NADH to NAD (+) ratio was reduced by quercetin ; half-maximal reduction occurred at a concentration of 32.6 microM. Additionally, quercetin (25 to 300 microM) stimulated the Krebs cycle ( (14)CO (2) production) and inhibited oxygen uptake (50 to 300 microM).”
The action of quercetin on the mitochondrial NADH to NAD(+) ratio in the isolated perfused rat liver.“It is concluded that quercetin can inhibit both glucose degradation and production and increase the cytosolic NAD + /NADH ratio.”
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