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Last Updated: 2 years ago

Possible Interaction: NAD and Quercetin

supplement:

NAD

supplement:

Quercetin

Research Papers that Mention the Interaction

2-Chloro-1,4-naphtoquinone-quercetin also showed potent inhibition against SIRT2, with an IC50 value of 14 μM. Diquercetin increased the Km value of NAD+ , whereas 2-chloro-1,4-naphthoquinone-quercetin increased the Km value of the acetylated substrate.
Overall, the results of in vitro studies and molecular modeling indicate that diquercetin competes with nicotinamide adenine dinucleotide (NAD+), whereas 2-chloro-1,4-naphthoquinone-quercetin competes with the acetylated substrate in the catalytic site of SIRT6.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2019  |  View Paper
The authors reported that quercetin in MCAO-induced ischemia modulated the expression of the enzymes isocitrate dehydrogenase [ NAD+ ] (which is present in two isoforms, EC.
Neurochemical Research  •  2018  |  View Paper
The NADH to NAD (+) ratio was reduced by quercetin ; half-maximal reduction occurred at a concentration of 32.6 microM. Additionally, quercetin (25 to 300 microM) stimulated the Krebs cycle ( (14)CO (2) production) and inhibited oxygen uptake (50 to 300 microM).
Planta medica  •  2005  |  View Paper
It is concluded that quercetin can inhibit both glucose degradation and production and increase the cytosolic NAD + /NADH ratio.
Xenobiotica; the fate of foreign compounds in biological systems  •  2003  |  View Paper