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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
NAD
Research Papers that Mention the Interaction
“To better understand the mechanisms that determine the response to PARP inhibitors, we investigated whether enzymes involved in metabolism of the PARP substrate, β‐NAD+ , might alter the response to a clinical PARP inhibitor.”
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells“The inhibition of DFF40 activity in the presence of NAD+ was reduced by co-incubation with poly(ADP-ribose) glycohydrolase and a PARP inhibitor.”
“PARP inhibitors PARPi ) are able to interact with the binding site for PARP cofactor ( NAD+ ) and trapping PARP on the DNA.”
“The PARP inhibitor 3-AB prevented the loss of NAD and ATP.”
“Intracellular NAD levels also increased significantly after treatment with IFN-γ in the presence of a PARP inhibitor.”
“This copurified activity was found to be suppressed under conditions where the poly(ADP-ribosylation ) reaction occurs in the presence of NAD.”
DNA topoisomerase I from calf thymus is inhibited in vitro by poly(ADP-ribosylation).“ PARP inhibitors do not affect the level of condensation of undamaged DNA but act to block condensation reversal for damaged DNA in the presence of NAD+.”
Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization
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