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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ NAD+ and NADH represent an important redox couple in energy metabolism.”
TEMPOL increases NAD+ and improves redox imbalance in obese mice“We found that treatment of astrocytes with NADH led to increases in both intracellular NADH and NAD+.”
“The intermediate nature of this mixture was determined spectrophotometrically when it was shown to drive the production of NADH when added to ADH and NAD.”
“ADP and ATP moderately, whereas NADH strongly inhibited the AsV reductase activity of the enzyme even in the presence of NAD.”
“NAD+ affinity was estimated by measuring the loss of the fluorescence blue shift as NADH dissociates on addition of NAD+.”
“This model requires differential binding affinities of NAD+ and NADH , which has been controversial.”
“ NADH was a competitive inhibitor with respect to NAD+ (Ki = 122 +/- 86 microM).”
“The amounts of beta-apo-carotenals and retinoids formed were markedly reduced when NAD+ was replaced by NADH , or when dithiothreitol and cofactors were deleted from the incubation mixture.”
“Product inhibition studies indicated that 15-keto-prostaglandin E2 exhibited linear non-competitive inhibtion with respect to either prostaglandin E2 or NAD+, and NADH yielded linear competitive inhibition with respect to NAD+.”
“The ratio of NAD + to NADH in each of the tissues analyzed was substantially greater than 1·0, varying from 1·9 in rabbit corneal epithelium to 5·5 in bovine corneal epithelium.”
“The structural data also show that NADH can compete with NAD to bind to the active site and inhibits the activity of the αβ heterodimer.”
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