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“ NAD inhibited anti-CD3 induced activation of splenic T cells in vitro and also retarded killing of beta-cell targets by NOD islet-reactive CD8 effectors in vitro at concentrations equal to or greater than 1 μmol/l.”
“An inverse correlation was observed between NAD+ concentration in the medium and the ability of rat T cells to respond to anti-CD3 , ConA, and PMA plus ionomycin.”