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“We have further demonstrated that exposure of Isoniazid, Bedaquiline , Rifampicin, and O-floxacin results in higher NADH: NAD+ ratios in the Mtb residing in macrophages.”
Front. Cell. Infect. Microbiol. • 2016 | View Paper
“Due to the NAD cofactor’s crucial role in cellular energy production, additional synergistic correlations of NAD biosynthesis blockade can be envisioned with bedaquiline and other drugs targeting energy-metabolism in mycobacteria.”