Possible Interaction: NAD and Adrenocorticotropic Hormone

“Based on our previous findings that activation of ACTH signaling changes the ratio of nicotinamide adenine dinucleotide (NAD) phosphate to reduced NAD phosphate in adrenocortical cells, we hypothesized that pyridine nucleotide metabolism may regulate the activity of the mitochondrial NAD(+)-dependent sirtuin (SIRT) deacetylases.”

“In the induced synthesis of DPN the injection of insulin, or ACTH , has been found to interfere with this process, giving a decrease in the elevated content of DPN.”