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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Liver cytosolic level of AA was increased (32%) after 6 h MDMA treatment.”
Acute administration of 3,4-methylenedioxymethamphetamine (MDMA) induces oxidative stress, lipoperoxidation and TNFα-mediated apoptosis in rat liver.“The adminstration of Vit C 30 min before MDMA treatment and 3 h after MDMA … not curb the decrease of ATP, 5-HT and the expression of SERT mRNA, but Vit C administrated 5 … after MDMA treatment could curb the decrease of ATP … the functional markers of 5-HT.”
“ Ascorbic acid also attenuated the MDMA‐induced depletion of striatal 5‐HT content.”
“Finally, a neurotoxic regimen of MDMA produced significant reductions in the concentrations of vitamin E and ascorbic acid in the striatum and hippocampus.”
“The concomitant administration of ascorbic acid with the neurotoxic regimen of MDMA prevented the diminished neurochemical and behavioral responses to a subsequent injection of MDMA.”
“Treatment of rats with ascorbic acid suppressed the generation of hydroxyl radicals, as evidenced by the production of 2,3‐dihydroxybenzoic acid from salicylic acid, in the striatum during the administration of a neurotoxic regimen of MDMA.”
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