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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Myricetin
drug:
Paclitaxel
Research Papers that Mention the Interaction
“Nine phenolic antioxidants ((+)-catechin, (-)-epicatechin, fisetin, gallic acid, morin, myricetin , naringenin, quercetin and resveratrol) were tested for inhibition of paclitaxel metabolism.”
Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants“It was also determined that the pre-incubation of ovarian cancer cells with a lower dose of myricetin was able to increase the cytotoxicity of paclitaxel , due to the significant downregulation of MDR-1 in these cells.”
Myricetin induces apoptosis and enhances chemosensitivity in ovarian cancer cells.
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