Possible Interaction: Muscarinic Antagonists and Progesterone

“These results demonstrate (i) that both carbachol‐ and veratridine‐induced down‐regulation of the mACh receptor is limited during the critical …) that after 3 months of age mACh receptor number is gradually declining, and (iii) that the steroid hormones oestrogen and progesterone are … of muscarinic antagonist binding sites … cortex.”

“Intraventricular infusion of the muscarinic antagonist scopolamine (10 micrograms bilaterally) which binds with high affinity to both M1 and M2 subtypes inhibited sexual behavior, as indicated by the incidence of lordosis, in ovariectomized rats treated with estrogen and progesterone.”