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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“ Muscarinic antagonists can mimic and enhance effects of cocaine , including discriminative stimulus (SD) effects, but the receptor subtypes mediating those effects are not known.”
Effects of muscarinic receptor antagonists on cocaine discrimination in wild-type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice“Drug interaction studies showed that the antimuscarinics , atropine and scopolamine, potentiated rather than attenuated the locomotor stimulant and cocaine-like discriminative-stimulus effects of cocaine , indicating that the antimuscarinic effects of the 3alpha-diphenylmethoxytropane analogs did not contribute to their diminished cocaine-like activity.”
“The antimuscarinic effect of cocaine may play an important role in cocaine cardiotoxicity by reducing the membrane electrical stability and acting synergistically with other actions of cocaine to facilitate the occurrence of lethal cardiac arrhythmias.”
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