Possible Interaction: Muscarinic Agonists and Calcium Supplement

“Application of adrenergic or muscarinic agonists elevated intracellular calcium and evoked exocytosis, as indicated by an increase in membrane capacitance of single cells.”

“The muscarinic agonist stimulated the efflux of calcium outside the cell.”

“The application of alpha 1-adrenergic and muscarinic agonists , which increase the turnover of phosphatidylinositol, for 5 minutes before skinning the cells increased the sensitivity of the myofilaments to calcium , as indicated by a leftward shift of the tension-pCa relation, whereas beta-adrenergic stimulation induced a rightward shift.”

“ Muscarinic agonists and other ligands that inhibit the M-type potassium current of frog sympathetic neurons have weak inhibitory effects on the calcium current as well.”

“ Muscarinic agonists increase cell calcium (by activating the phosphoinositide pathway), which in tum causes fusion of the vesicle with the apical membranes, and release of the secreted proteins into the lumen of the ducts.”