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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Muromonab-Cd3
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Inhibition of Ca2+ signals is independent of the stimulation method as Ca2+ entry was blocked following stimulation with anti-CD3 , which activates the T-cell receptor, and also following stimulation with thapsigargin or inositol 1,4,5-trisphosphate.”
Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2*“Furthermore, stimulation of one of these clones with anti-CD3 mAbs results in a rapid rise in intracellular calcium.”
“The rise in intracellular calcium in MRL vs controls was enhanced and prolonged following anti-CD3 triggering, suggestive of proximal defects in TCR-engendered signaling as the mechanism for the observed hyperactivity.”
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation1
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