Possible Interaction: Multivitamin Preparation and Vitamin C

“ Multivitamin use, for example, declined from 37% to 31%, and rates of vitamin C , vitamin E, and selenium use decreased, perhaps in response to research findings showing no benefit.”

“Odds ratios for anencephaly with nitrosatable drug … reduced among women who also took daily vitamin supplements that contained vitamin C. Prenatal exposure to nitrosatable drugs may increase the risk of … defects, especially in conjunction with a mother's higher dietary intake of nitrites, but vitamin C might modulate … association.”

“ Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81–0.96).ConclusionsModest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer.”

“Recently, Xu et al. (2) showed that in women taking a multivitamin or supplements of vitamins C and E the length of telomeres was affected.”

“Recently, the US Food and Drug Administration required the dose of vitamin C in IV multivitamin preparations to be increased from 100 mg to 200 mg/d.”

“The use of iron (odds ratio, 0.43; P = … (odds ratio, 0.42; P = 0.05), and vitamin C (odds ratio, 0.35; P = 0.04) supplements … during the pregnancy and the use of multivitamins during the first six weeks (odds ratio, … = 0.02) were associated with decreased risk.”

“The multivitamin prevented the impairment of children providing with vitamins C and B6, and improved their provision with vitamins B1, B2 and PP.”

“ Ascorbic acid present in multivitamin samples interfered seriously with the analysis, and off-line sample treatment using anion exchange resin was employed to successfully remove ascorbic acid before the analysis.”

“CONCLUSION Exposure of MV s to light leads to the rapid loss of asc orbic acid an d generation of specific byproducts that differ from DHA and DKG.”

“Recently, the US Food and Drug Administration required the dose of vitamin C in IV multivitamin preparations to be increased from 100 mg to 200 mg/d.”