Possible Interaction: Multivitamin Preparation and Iron, Dietary

“The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins , including hemojuvelin, bone morphogenetic protein 6 (BMP6), hereditary hemochromatosis protein, transferrin receptor 2, matriptase-2, neogenin, BMP receptors, and transferrin.”

“However, evidence showed that women receiving multivitamins plus iron and folic acid had reduced risk for stillbirth.”

“Multivitamin supplementation There was evidence of a decrease in the risk for stillbirth among women receiving multivitamins plus iron and folic acid compared iron and folate only groups (RR 0.92, 95% CI 0.85 to 0.99, 10 trials, 79,851 women; high-quality evidence).”

“… iron (odds ratio, 0.43; P = 0.004), calcium (odds ratio, 0.42; P = 0.05), and vitamin …, 0.35; P = 0.04) supplements at any time during the pregnancy and the use of multivitamins during the first six weeks (odds ratio, … = 0.02) were associated with decreased risk.”

“Higher serum iron levels were identified in the animals that received chewable multivitamins with iron.”