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Possible Interaction: Moxonidine and Yohimbine



Research Papers that Mention the Interaction

L-NAME and idazoxan significantly reduced the relaxation caused by moxonidine (P < 0.05), while yohimbine significantly increased the relaxation by moxonidine (P < 0.05).
Interactive cardiovascular and thoracic surgery  •  2015  |  View Paper
The response of moxonidine was antagonized by either yohimbine , an alpha2 receptor antagonist, or efaroxan, an I1/alpha2 receptor antagonist.
Current eye research  •  2009  |  View Paper
Vasoconstrictive responses to lower but not higher concentrations of clonidine and moxonidine were inhibited by 0.1 microM yohimbine.
European journal of pharmacology  •  2008  |  View Paper
Yohimbine produced no change on rilmenidine effect but partially inhibited the moxonidine effect.
Autonomic Neuroscience  •  2004  |  View Paper
Combination drug treatment (urapidil and yohimbine, or yohimbine and prazosin) was more effective in blocking the contractile response to moxonidine , than treatment with prazosin or urapidil alone.
The response to moxonidine (1 microM) could be blocked by both alpha1-adrenoceptor blockers prazosin (IC50 = 1 nM), and urapidil (IC50 = 14 nM), and also by alpha2-adrenoceptor blockers, yohimbine (IC50 = 49 nM) and efaroxan (IC50 = 49 nM).
Journal of cardiovascular pharmacology  •  2004  |  View Paper
Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly.
Annals of the New York Academy of Sciences  •  2003  |  View Paper
In addition, the alpha(2)-adrenergic receptor antagonist yohimbine produced a dose-related antagonism of moxonidine , but only partially antagonized clonidine.
Pain  •  2000  |  View Paper
Both, the nonselective imidazoline/alpha 2-adrenoceptor antagonist idazoxan and the pure alpha 2-adrenoceptor antagonist yohimbine attenuated the moxonidine induced effects on fractional fluid excretion and Na+ excretion.
Clinical nephrology  •  1997  |  View Paper
Yohimbine (3 microM) and efaroxan (0.01 and 1 microM) caused parallel rightward shifts to the concentration-response curves of moxonidine and UK 14,304, yielding pKB values corresponding to those at alpha-2 binding sites.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
The effects of rilmenidine, moxonidine , and UK 14304 were antagonized by intravenously administered yohimbine , SK&F86466, and RX821002.
The effects of moxonidine and UK 14304 were also prevented by yohimbine injected into the cisterna magna.
Annals of the New York Academy of Sciences  •  1995  |  View Paper
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