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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Moxonidine
supplement:
Yohimbine
Research Papers that Mention the Interaction
“ Yohimbine , a non-imidazoline alpha 2-antagonist, was ineffective alone, or in combination with moxonidine (up to 40 microM), but yohimbine blocked NE's induction of the 85 kDa band.”
Imidazoline receptor proteins are regulated in platelet-precursor MEG-01 cells by agonists and antagonists.“L-NAME and idazoxan significantly reduced the relaxation caused by moxonidine (P < 0.05), while yohimbine significantly increased the relaxation by moxonidine (P < 0.05).”
“The response of moxonidine was antagonized by either yohimbine , an α2 receptor antagonist, or efaroxan, an I1/α2 receptor antagonist.”
Effect of Moxonidine on the Uveoscleral Outflow: Role of α2-Adrenoceptors or I1 Imidazoline Receptors“Vasoconstrictive responses to lower but not higher concentrations of clonidine and moxonidine were inhibited by 0.1 microM yohimbine.”
“The actions of 5 μg clonidine and 50 μg moxonidine were inhibited by yohimbine , an α2‐adrenoceptor antagonist, and efaroxan, an imidazoline I1‐receptor antagonist.”
“ Yohimbine produced no change on rilmenidine effect but partially inhibited the moxonidine effect.”
“Combination drug treatment (urapidil and yohimbine, or yohimbine and prazosin) was more effective in blocking the contractile response to moxonidine , than treatment with prazosin or urapidil alone.”
“ Yohimbine blocked hypotension, delayed bradycardia (8 nmol), or completely inhibited the effects of moxonidine (16 nmol).”
“ Yohimbine abolished the antidipsogenic effect of moxonidine intracerebroventricularly.”
“In addition, the &agr;2‐adrenergic receptor antagonist yohimbine produced a dose‐related antagonism of moxonidine , but only partially antagonized clonidine.”
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