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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The mechanism(s) by which vitamin C inhibits morphine dependence in not understood.”
Effect of Chronic Administration of Morphine on the Gene Expression Level of Sodium-Dependent Vitamin C Transporters in Rat Hippocampus and Lumbar Spinal Cord“ConclusionOur study showed that supplementation with vitamin C (2 g) po decreased morphine consumption in the postoperative period in patients undergoing laparoscopic cholecystectomy. (”
“The results obtained showed that morphine (1 mM), locally perfused into the NAc, significantly increased AA release in the NAc and also GABA release.”
GABAA receptors in VTA mediate the morphine-induced release of ascorbic acid in rat nucleus accumbens“The results showed that local perfusion of morphine (100 µM, 1 mM) in NAc dose‐dependently increased AA and GABA release, while attenuated Glu release in the NAc.”
“While given intra-accumbensally, morphine (1 mM), methamphetamine (250 microM) or nicotine (500 microM) increase AA release to 165, 160, 160%, respectively.”
“Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats.”
“When given intranigrally, morphine (1 mM) increased DOPAC+HVA, AA and uric acid and decreased glutamate dialysate concentrations over a 2 h period after morphine; DA and 5-HIAA concentrations were unaffected.”
“Recent ex vivo findings have shown that morphine increases dopamine (DA) and xanthine oxidative metabolism and ascorbic acid (AA) oxidation in the rat striatum.”
“… ascorbic acid (… morphine in humans and rodents, levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxytyramine (3-MT), 5-hydroxytryptamine (5-HT), 5-…-pressure liquid chromatography (HPLC) in the striatum and in the limbic forebrain of the rat following morphine treatment (single or repeated) and withdrawal.”
“However, at ED20, combination of ascorbic acid and tramadol or morphine showed synergic effects.”
“The interaction index demonstrated additive effects at ED50 and ED65 for co-administration of ascorbic acid and tramadol or morphine.”
Ascorbic Acid Interaction With Analgesic Effect of Morphine and Tramadol in Mice“Conclusion: The chronic administration of AA may prevent the development of tolerance and physical dependence on morphine self-administration via the glutamatergic system.”
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