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Last Updated: 6 months ago

Possible Interaction: Morphine and Tyrosine

supplement:

Tyrosine

Research Papers that Mention the Interaction

Morphine and β‐endorphine increased the concentrations of tyrosine and tryptophan, and naloxone decreased the cerebral tryptophan concentration.
The Journal of pharmacy and pharmacology  •  1978  |  View Paper
In addition, morphine treatment induced the expression of suppressor of cytokine signaling protein-1, 2, 3 (SOCS-1, 2, 3) and protein inhibitors of activated STAT-1, 3, X, Y (PIAS-1, 3, X, Y), the key negative regulators of IFN signaling pathway.
PloS one  •  2012  |  View Paper
In addition, morphine inhibited peroxynitrite-induced nitration of tyrosine in a concentration-dependent manner.
European journal of pharmacology  •  1999  |  View Paper
Furthermore, we show by site-directed mutagenesis that tyrosine (Y382–384) within the P2X7R C-terminus is differentially modulated by repeated morphine treatment and has no bearing on normal P2X7R function.
The Journal of Neuroscience  •  2017  |  View Paper
Both morphine and methadone increased the cerebral concentrations of tryptophan and tyrosine and naloxone antagonized these effects.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Morphine also resulted in IRS-1 phosphorylation at serine 612 and reduced tyrosine phosphorylation at the YMXM p85-binding motifs, weakening the association of the IRS-1/p85 phosphatidylinositol 3-kinase complex.
Molecular and Cellular Biology  •  2003  |  View Paper
Acute administration of morphine (5, 10 and 20 mg/kg) produced dose-dependent increases in blood glucose concentration which were insignificantly potentiated by L-tyrosine (25-200 mg/kg) when given together with morphine.
General pharmacology  •  1995  |  View Paper
L-TYR (200 mg/kg) significantly potentiated (P < .05) the analgesic activity of morphine sulfate (10 mg/kg) and codeine sulfate (30 mg/kg).
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
Morphine , at a concentration of 1 x 10(-5)M increases the incorporation of tritiated tyrosine into dopamine and dihydroxy phenylacetic acid in synaptosomal preparations.
Biochemistry and molecular biology international  •  1994  |  View Paper
Acute morphine sulfate (50 mg/kg) increased dihydroxyphenylacetic acid/dopamine ratios (DOPAC/DA) (+20%), the conversion of [3H]tyrosine to [3H]dopamine (+73%) and open-field activity (+130%) in CD-1 male mice.
Pharmacology Biochemistry and Behavior  •  1986  |  View Paper
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