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Last Updated: 6 months ago

Possible Interaction: Morphine and Tyrosine



Research Papers that Mention the Interaction

Morphine and β‐endorphine increased the concentrations of tyrosine and tryptophan, and naloxone decreased the cerebral tryptophan concentration.
The Journal of pharmacy and pharmacology  •  1978  |  View Paper
In addition, morphine treatment induced the expression of suppressor of cytokine signaling protein-1, 2, 3 (SOCS-1, 2, 3) and protein inhibitors of activated STAT-1, 3, X, Y (PIAS-1, 3, X, Y), the key negative regulators of IFN signaling pathway.
PloS one  •  2012  |  View Paper
In addition, morphine inhibited peroxynitrite-induced nitration of tyrosine in a concentration-dependent manner.
European journal of pharmacology  •  1999  |  View Paper
Furthermore, we show by site-directed mutagenesis that tyrosine (Y382–384) within the P2X7R C-terminus is differentially modulated by repeated morphine treatment and has no bearing on normal P2X7R function.
The Journal of Neuroscience  •  2017  |  View Paper
Both morphine and methadone increased the cerebral concentrations of tryptophan and tyrosine and naloxone antagonized these effects.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Morphine also resulted in IRS-1 phosphorylation at serine 612 and reduced tyrosine phosphorylation at the YMXM p85-binding motifs, weakening the association of the IRS-1/p85 phosphatidylinositol 3-kinase complex.
Molecular and Cellular Biology  •  2003  |  View Paper
Acute administration of morphine (5, 10 and 20 mg/kg) produced dose-dependent increases in blood glucose concentration which were insignificantly potentiated by L-tyrosine (25-200 mg/kg) when given together with morphine.
General pharmacology  •  1995  |  View Paper
L-TYR (200 mg/kg) significantly potentiated (P < .05) the analgesic activity of morphine sulfate (10 mg/kg) and codeine sulfate (30 mg/kg).
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
Morphine , at a concentration of 1 x 10(-5)M increases the incorporation of tritiated tyrosine into dopamine and dihydroxy phenylacetic acid in synaptosomal preparations.
Biochemistry and molecular biology international  •  1994  |  View Paper
Acute morphine sulfate (50 mg/kg) increased dihydroxyphenylacetic acid/dopamine ratios (DOPAC/DA) (+20%), the conversion of [3H]tyrosine to [3H]dopamine (+73%) and open-field activity (+130%) in CD-1 male mice.
Pharmacology Biochemistry and Behavior  •  1986  |  View Paper
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