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Possible Interaction: Morphine and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

When plasma tryptophan falls below normal levels, brain 5-HT falls and morphine requirements are reduced.
Pharmacology Biochemistry and Behavior  •  1990  |  View Paper
Chronic administration of morphine , nicotine or phenobarbitone has previously been shown to inhibit rat liver tryptophan pyrrolase activity by increasing hepatic [NADPH], whereas subsequent withdrawal enhances pyrrolase activity by a hormonal-type mechanism.
The Biochemical journal  •  1981  |  View Paper
Serotonin precursors, 5-HTP and TP evidently potentiated the morphine induced catalepsy.
Polish journal of pharmacology and pharmacy  •  1979  |  View Paper
Morphine and β‐endorphine increased the concentrations of tyrosine and tryptophan , and naloxone decreased the cerebral tryptophan concentration.
The Journal of pharmacy and pharmacology  •  1978  |  View Paper
Daily tryptophan administration to rats and mice during a 3-day morphine pellet implantation period increased the rates of both morphine tolerance development and development of physical dependence.
The Journal of pharmacology and experimental therapeutics  •  1975  |  View Paper
Both morphine and methadone increased the cerebral concentrations of tryptophan and tyrosine and naloxone antagonized these effects.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The possible involvement of hepatic tryptophan metabolism in morphine dependence is briefly discussed.
British journal of pharmacology  •  1981  |  View Paper
A large dose of tryptophan antagonised the antinociceptive action of morphine in the rat.
An acute dose of morphine increased brain tryptophan in mice.
Morphine increased brain tryptophan in rats.
Journal of neuroscience research  •  1979  |  View Paper
Abstract Morphine increased brain concentrations of tryptophan and tyrosine 1–2 hr after administration in a dose-dependent manner in male rats.
Neuropharmacology  •  1978  |  View Paper
Morphine induces naloxone-reversible increases of tryptophan and 5-hydroxyindoles in rat cerebral hemispheres, thalamus and cerebellum, but does not do so in striatum, hypothalamus, hippocampus and brain stem.
European journal of pharmacology  •  1978  |  View Paper
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