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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ Taurine induced a hyperalgesic state and attenuated morphine analgesia in mice.”
Effects of taurine on tolerance to and dependence on morphine in mice.“It was found that taurine significantly increased the viability of C6 cells treated by morphine , showing the neuroprotective role against morphine-induced neurotoxicity.”
Protective Role of Taurine Against Morphine-Induced Neurotoxicity in C6 Cells via Inhibition of Oxidative Stress“The analgesic response to morphine was also reduced by inclusion of taurine in the drinking water.”
“The analgesic effect of morphine was antagonized in mice by intracerebroventricular pretreatment with taurine , gamma-aminobutyric acid (GABA) or glycine and was potentiated by ethylene glycol tetra-acetic acid (EGTA) but not altered by L-glutamate or L-aspartate.”
“The selective depletion of 45Ca2+ from synaptic vesicles observed with morphine administration was significantly inhibited by taurine injection (1.2 mumol/brain, i.vt.)”
“These results suggest that antagonism of morphine analgesia by taurine may be caused by blockade of the morphine-induced inhibition of both ATP-dependent synaptosomal 45Ca2+ uptake and changes in synaptic vesicular 45Ca2+ localization, while the antagonism by GABA was not associated with synaptosomal Ca2+.”
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