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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Morphine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Our findings indicate that, in clinical practice, SJW could reduce the dose of morphine obtaining the same analgesic effect.”
“Phosphorylation of the γ subunit of PKC enzyme was assayed by western blotting in the periaqueductal grey … (PAG) from rodents co-administered with morphine and hypericin and was prevented in rodent PAG by SJW or hypericin co-administration with morphine , inducing a potentiation of morphine analgesia in thermal pain.”
“The score of pain assessment in healthy volunteers were decreased by 40% when morphine was co-administered with SJW at a dose largely below those used to obtain an antidepressant or analgesic effect in both rodents and humans.”
PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans.“The withdrawal behavioral manifestations in rats were inhibited significantly by chronic co‐administration of Hypericum perforatum extract or clonidine with morphine.”
“but at a dose of 1.2 mL/200 g of HPE was significantly stronger than clonidine in attenuation of the morphine withdrawal syndrome.”
The inhibitory effect of Hypericum perforatum extract on morphine withdrawal syndrome in rat and comparison with clonidine
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