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“Morphine decreased the NMDA receptor‐mediated excitatory postsynaptic currents and excitability of GABAergic neurons in the NAc, while exogenous d‐serine alleviated the effects of morphine.”
“While the intracerebroventricular (icv) administration of morphine to mice rapidly reduced the association of MORs with G proteins, it increased the serine phosphorylation of these receptors.”
“In addition, we showed that the ability of morphine withdrawal to stimulate phosphorylation at serine 31 is reduced (101.7 ± 7.7%, P < 0.05) by SL327 (100 mg/kg, i.p.),”