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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Morphine and Secretin

supplement:

Secretin

Research Papers that Mention the Interaction

Intravenous infusion of a small dose of morphine , 40 microgram/kg/h, during pancreatic stimulation with secretin and cholecystokinin, caused a significant increase in volume, bicarbonate, and calcium secretion, and a significant decrease in protein secretion.
Gut  •  1982  |  View Paper
Morphine given with the secretin augmented the effect on lymph enzyme levels.
Gastroenterology  •  1960  |  View Paper
However, it depressed the acute nociceptive effect of a single subcutaneous (SC) dose of morphine (4 mg/kg) after ICV (1 or 10 ng/animal) secretin administration.
These data suggest that central secretin administration can modify the analgesic effect of morphine.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper