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Last Updated: 2 years ago

Possible Interaction: Morphine and Progesterone

supplement:

Progesterone

Research Papers that Mention the Interaction

In a series of studies, Concas et al. show that acute and chronic administration of nicotine and morphine modulate both central and peripheral levels of progesterone , pregnenolone, and allopregnanolone (3α5α tetrahydroprogesterone; 3α-5α THP).
Psychopharmacology  •  2006  |  View Paper
Animals treated with progesterone during late pregnancy and challenged with morphine during lactation exhibited a significant decrease in maternal behavior in both Experiments 2 and 3.
Pharmacology Biochemistry and Behavior  •  2015  |  View Paper
beta-endorphin (beta-EP) stimulated progesterone production in a dose-dependant manner (10(-8)-10(-6) mol/L); dynorphin exhibited a stimulatory effect only …/L, while Met-enkephalin had no substantial effect at dose from 10(-10)-10(-6) mol/L. mu-opioid receptor agonists DAGO and morphine … progesterone ….
Sheng li xue bao : [Acta physiologica Sinica]  •  1992  |  View Paper
Chronic morphine treatment induced a supersensitivity state in the uteri from both progesterone and estradiol treated mice.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1987  |  View Paper
Administration of the opiate agonist, morphine , to estrogen/progesterone pretreated females decreased LH and decreased the depletion of the catecholamines in the above mentioned areas, suggesting reduced activity.
Neuroendocrinology  •  1984  |  View Paper
We now report that the intrathecal injection of morphine into female ovariectomized rats pretreated with oestradiol benzoate and progesterone inhibits sexual receptivity while injection of the opiate receptor antagonist naloxone enhances it.
Nature  •  1984  |  View Paper
Morphine significantly increased brain and plasma concentrations of several steroids (including progesterone , deoxycorticosterone, corticosterone, and their metabolites) likely via activation of the hypothalamic-pituitary-adrenal stress axis.
Neurobiology of Stress  •  2020  |  View Paper