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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.”
“There was a significant reduction in oxytocin response following morphine administration when compared to placebo but not between naloxone and placebo.”
Morphine Suppresses the Oxytocin Response in Breast-Feeding Women“RESULTS Mo phine ad ministered IV significantly inhibited REMP amplitude, compared with IV administration of saline solution or oxy tocin. ”
Effect of intrathecal and intravenous administration of oxytocin on amplitude of the reflex-evoked muscle action potential after electrical stimulation of the tooth pulp in anesthetized dogs.“In both the CellKey™ assay and the intracellular cAMP assay, OT alone exerted no direct agonistic effect on human MOR, but treatment with 10-6 M OT markedly enhanced the MOR signaling induced by 10-6 M endomorphin-1, β-endorphin, morphine , fentanyl, and DAMGO.”
“ OXT acts within the CNS and has been shown to inhibit the development of tolerance to morphine , and to attenuate various symptoms of morphine withdrawal in mice.”
“Local IC microinjection of OXT in physiological doses into the posterior olfactory nucleus, tuberculum olfactorium, nucleus accumbens, central amygdaloid nucleus, and the hippocampus inhibited the development of tolerance to and dependence on morphine as well as cocaine-induced sniffing behavior and tolerance to cocaine.”
“ OXT inhibited the development of tolerance to morphine , heroin, beta-endorphin, and enkephalin, OXT also inhibited the development of cross-tolerance between the predominantly mu-agonist heroin and the predominantly delta-agonist enkephalin in mice.”
“ Oxytocin and the dipeptides attenuated the development of acute and chronic tolerance to the antinociceptive effect of morphine and delayed the onset of the naloxone-precipitated withdrawal syndrome.”
“In addition, oxytocin in the mPFC improved memory function and prevented memory impairment-induced by morphine.”
“Here, the classical μ-opioid receptor agonist, morphine robustly inhibited the spontaneous firing rate of vasopressin and oxytocin neurons, and this inhibition was attenuated by pretreatment with the NPFFR1 agonist, RFamide-related peptide-3.”
“Naloxone-induced morphine withdrawal strongly increased the firing rate of oxytocin neurons in morphine dependent rats.”
“While exogenous glucocorticoids could not induce the disturbance, morphine caused inhibition of oxytocin release during milking.”
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