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Last Updated: 3 months ago

Possible Interaction: Morphine and Glutamic Acid

supplement:

Glutamic Acid

Research Papers that Mention the Interaction

Glutamic acid and ketamine, partially blocked the analgesic effects of morphine.
Indian journal of physiology and pharmacology  •  2000  |  View Paper
In rats, pretreated with naloxone, there was restoration as well as augmentation of morphine- induced antinociception in the presence of L- glutamic acid with an increase in TFL (9.0 ± 0.4 sec; P < 0.0001).
Intrathecal administration of L- glutamic acid attenuated the antinociceptive effect of intrathecal morphine with a decrease in TFL (1.4 ± 0.3 sec; P < 0.0001) from 6.6 ± 0.3 sec. Ketamine led to abolition of this effect (P < 0.01).
Canadian journal of anaesthesia = Journal canadien d'anesthesie  •  1995  |  View Paper
On the contrary, excitatory effect of glutamic acid decreased only when morphine was applied in doses causing local anesthetic effect and decreasing background neuronal activity.
Biulleten' eksperimental'noi biologii i meditsiny  •  1986  |  View Paper
Both morphine and reserpine, in vivo, inhibited the spontaneous glutamic acid release but not the loss of glutamic acid due to pulses.
Psychopharmacology communications  •  1975  |  View Paper
Five minutes after the injection of morphine sulfate, a statistically significant degree of inhibition of glutamic acid breakdown was present.
Biochemical pharmacology  •  1964  |  View Paper