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Last Updated: 2 years ago

Possible Interaction: Morphine and Calcium Supplement

Research Papers that Mention the Interaction

Morphine induced a dose-dependent rise in intracellular calcium in neurons from wild-type animals.
Molecular pain  •  2009  |  View Paper
Acute subcutaneous injection of 25 mg/kg of morphine in rats decreased synaptosomal CA++ levels by 29% without altering the Ca++ content of other subcellular fractions.
The Journal of pharmacology and experimental therapeutics  •  1978  |  View Paper
Harris et a[. [I21 have demonstrated that prior administration of calcium (as well as magnesium or manganese) to mice prevented the analgesic effect of a single dose of morphine and also that calcium was a more effective antagonist in morphinetolerant mice than in nontolerant animals.
Intracisternal or subcutaneous administration of calcium prevented the analgesic effect of morphine and meperidine in mice and guinea pigs respectively [S, 91.
The acute administration of morphine produced a decrease of tissue calcium in discrete regions of rat brain [ll].
Biochemical pharmacology  •  1977  |  View Paper
Abstract In rats made dependent on morphine , brain levels of calcium were significantly lowered.
It is suggested that the antagonistic actions of calcium and morphine may be related to their effects on morphine-sensitive adenylate cyclase activity.
Life sciences  •  1976  |  View Paper
The potency of morphine in producing responses of the ileum was reduced in the presence of raised concentrations of calcium , indicating that the effect of morphine may be mediated via a calcium-sensitive step.
Archives internationales de pharmacodynamie et de therapie  •  1975  |  View Paper
Morphine increased the content of intracellular calcium in a time-dependent manner.
Toxicology in vitro : an international journal published in association with BIBRA  •  2004  |  View Paper
Both morphine and anandamide significantly stimulated cultured endothelial intracellular calcium level increases in a concentration-dependent manner in cells pre-loaded with fura 2/AM.
Cellular signalling  •  1999  |  View Paper
Calcium introduced into the cerebrospinal fluid of experimental animals is said to cause drowsiness, but to antagonize the analgesic action of morphine (Kakunaga et al. 1966).
Psychological medicine  •  1977  |  View Paper
This study demonstrates the potential activity of the co-administration calcium and magnesium in preventing the signs associated with morphine withdrawal syndrome.
Magnesium research  •  2012  |  View Paper
Intraperitoneal injection of morphine (6 mg/kg) induced significant inhibition of salivary flow rate, total protein, calcium , and TGF-beta1 concentrations.
Acta biologica Hungarica  •  2006  |  View Paper
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