Possible Interaction: Morphine and Calcium Supplement

“ Morphine induced a dose-dependent rise in intracellular calcium in neurons from wild-type animals.”

“Acute subcutaneous injection of 25 mg/kg of morphine in rats decreased synaptosomal CA++ levels by 29% without altering the Ca++ content of other subcellular fractions.”

“Harris et a[. [I21 have demonstrated that prior administration of calcium (as well as magnesium or manganese) to mice prevented the analgesic effect of a single dose of morphine and also that calcium was a more effective antagonist in morphinetolerant mice than in nontolerant animals.”

“Intracisternal or subcutaneous administration of calcium prevented the analgesic effect of morphine and meperidine in mice and guinea pigs respectively [S, 91.”

“The acute administration of morphine produced a decrease of tissue calcium in discrete regions of rat brain [ll].”

“Abstract In rats made dependent on morphine , brain levels of calcium were significantly lowered.”

“It is suggested that the antagonistic actions of calcium and morphine may be related to their effects on morphine-sensitive adenylate cyclase activity.”

“The potency of morphine in producing responses of the ileum was reduced in the presence of raised concentrations of calcium , indicating that the effect of morphine may be mediated via a calcium-sensitive step.”

“ Morphine increased the content of intracellular calcium in a time-dependent manner.”

“Both morphine and anandamide significantly stimulated cultured endothelial intracellular calcium level increases in a concentration-dependent manner in cells pre-loaded with fura 2/AM.”

“ Calcium introduced into the cerebrospinal fluid of experimental animals is said to cause drowsiness, but to antagonize the analgesic action of morphine (Kakunaga et al. 1966).”

“This study demonstrates the potential activity of the co-administration calcium and magnesium in preventing the signs associated with morphine withdrawal syndrome.”

“Intraperitoneal injection of morphine (6 mg/kg) induced significant inhibition of salivary flow rate, total protein, calcium , and TGF-beta1 concentrations.”