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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Morphine and Ascorbate

supplement:

Ascorbate

Research Papers that Mention the Interaction

In mice ascorbate , when co-administered with morphine , suppresses the development of tolerance and physical dependence on the drug, without significantly affecting its analgesic properties as inferred from unaltered ED50 values.
Life sciences  •  1983  |  View Paper
Morphine administration increased the striatal levels of DA metabolites, UA and DHAA and the extracellular concentrations of DA, DOPAC + HVA, UA and AA.
Pharmacological research  •  1997  |  View Paper
It is postulated that ascorbate antagonizes the lethality of morphine by selectively affecting neuronal activity.
Neuropharmacology  •  1985  |  View Paper
Ascorbate doses over 8 mg/kg also protected mice from lethal doses of morphine.
Oral administration of single doses of ascorbate produced a decrease in the analgesic effect of morphine in mice when assayed by the tail-flick test.
Research communications in chemical pathology and pharmacology  •  1983  |  View Paper