supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In mice ascorbate , when co-administered with morphine , suppresses the development of tolerance and physical dependence on the drug, without significantly affecting its analgesic properties as inferred from unaltered ED50 values.”
Megadoses of vitamin C prevent the development of tolerance and physical dependence on morphine in mice.“ Morphine administration increased the striatal levels of DA metabolites, UA and DHAA and the extracellular concentrations of DA, DOPAC + HVA, UA and AA.”
Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies.“It is postulated that ascorbate antagonizes the lethality of morphine by selectively affecting neuronal activity.”
“ Ascorbate doses over 8 mg/kg also protected mice from lethal doses of morphine.”
“Oral administration of single doses of ascorbate produced a decrease in the analgesic effect of morphine in mice when assayed by the tail-flick test.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback