Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Monoamine Oxidase Inhibitors and Phenethylamines

Research Papers that Mention the Interaction

Phenylethylamine concentrations are increased primarily by phenylalanine, its amino acid precursor and by such monoamine oxidase inhibitors as L-deprenyl and pargyline.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1984  |  View Paper
Acute pretreatment with either a Type A monoamine oxidase inhibitor MAOI ), clorgyline, or a Type B MAOI, pargyline, markedly reduced the dose of phenylethylamine (PEA) required to produce checking and a variety of other behavioral changes in rhesus monkeys.
Biological psychiatry  •  1980  |  View Paper
These patients were generally nonresponsive to the usual treatment modalities, and their symptoms were exacerbated by nonspecific monoamine oxidase inhibitors which further increased PEA excretion rates.
Psychiatry Research  •  1982  |  View Paper
The brain content of phenylethylamine in mice (Mosnaim and Sabelli, 1971), rabbits (Sabelli, Giardina, Mosnaim and Inwang, 1972) and rats (Fischer, Spatz, Heller and Reggiani, 1972) is increased by antidepressive treatments (imipramine, monoamine oxidase inhibitors , electroshock) and reduced by reserpine.
Journal of neurochemistry  •  1973  |  View Paper
Jepson et al.3 have recently shown that administration of a monoamine oxidase inhibitor to phenylketonuric individuals results in an increase much greater than normal in the urinary excretion of phenylethylamine , but not of o-tyramine.
Nature  •  1961  |  View Paper
Difluorophenylethylamine caused increased locomotor activity in mice, and its effects were enhanced by a monoamine oxidase inhibitor (tranylcypromine) as were the effects of phenylethylamine.
Psychopharmacologia  •  2004  |  View Paper
The effects of tyrosine and phenylethylamine were greatly increased by pretreatment with a monoamine oxidase inhibitor.
Journal of neurochemistry  •  1976  |  View Paper