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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mitotane
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“We found that in the AtT20/D16v-F2 cell line and in primary cultures, mitotane reduces cell viability by inducing caspase-mediated apoptosis and reduces ACTH secretion.”
Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function.“CONCLUSIONS The observation of lower ACTH levels in patients with ACC than that in patients with PAI, both in basal conditions and after CRH stimulation, suggests that mi otane ma y play an inhibitory effect on ACT H se cretion at the pituitary levels.”
“Early biochemical indicators of adrenal suppression with mitotane were a sharp decrease in adrenal response to the infusion of ACTH and in plasma levels of dehydroepiandrosterone sulfate.”
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