Possible Interaction: Mitomycin and Vitamin K

“Despite preclinical evidence indicating that menadione pretreatment enhances the cytotoxicity of mitomycin C , our study documents the resistance of advanced gastrointestinal cancers, particularly colorectal cancer, to mitomycin C modulated by menadione.”

“All three patients treated with menadione at 8.0 g/m2 and the single patient treated at 4.0 g/m2 with mitomycin C at 5 mg/m2 developed clinically significant hemolysis despite the presence of red blood cell glucose-6-phosphate dehydrogenase.”

“In addition, PMS, MEN and MB were found to decrease the cytotoxicity of MMC , by 90, 63 and 29%, respectively, at concentrations that were themselves completely nontoxic.”

“ MITO and vitamin K3 in combination effected an enhanced inhibition of [3H]thymidine (DNA synthesis) and [3H]uridine (RNA synthesis) and also Increased the life span of the sensitive and resistant tumor-bearing animals.”

“ Vitamin K3 potentiated the antitumor effects of MITO in P388/S and P388/ ADR tumor cells as monitored by inhibition of tumor cell survival (MTT assay).”