supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Cell division delays caused by MMC was reversed in the presence of AA.”
Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro.“Several reports in the literature indicate that ascorbic acid can modulate the cytotoxic effects of mitomycin C , either potentiating or inhibiting its effects.”
Reductive activation of mitomycins A and C by vitamin C.“On the other hand, V-C induced a slight decrease in cell proliferation that was stronger when combined with MMC.”
“The results showed that V-C caused a strong inhibition of SCEs induced by MMC in the three dosages administered.”
“ Ascorbic acid had a powerful stimulatory effect on the MMC-induced lipid peroxidation, while it produced only a small increase in the MMC accumulation.”
“This results suggests that ascorbic acid increases slightly the accumulation of MMC , but that the stimulatory action of ascorbic acid on the MMC-induced lipid peroxidation cannot be explained simply by the increase in the MMC accumulation.”
“The presence of ascorbic acid in the exposure medium (0.284 mM) increased the aerobic but not the hypoxic cytotoxicity of MMC.”
“The stimulation of lipid peroxidation by MC , NF or PQ was inhibited significantly by superoxide dismutase, glutathione, ascorbic acid , catalase and EDTA, agents which either scavenge reactive oxygen and/or prevent the generation of secondary reactive oxygen metabolites.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback