Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Mitomycin and Quercetin



Research Papers that Mention the Interaction

Concentrations of 0.03, 0.15, 0.3, 0.6, 1.5 and 3mM quercetin significantly reduced the DNA strand breakage induced by mitomycin C (P<0.001) but the highest concentration of 6mM quercetin did not show a protective effect.
Thus, in human lymphocytes quercetin and rutin displayed protective effects on DNA damage induced by mitomycin C , in a concentration-dependent manner.
Toxicology letters  •  2004  |  View Paper
Quercetin was found to be also an effective protector … damage induced by mitomycin C. CONCLUSION We conclude that quercetin , one of the most abundant flavonoids in the human diet, is highly … in reducing the DNA damage caused by the antitumor agents, idarubicin and mitomycin C , following bioactivation … P450 reductase.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques  •  2010  |  View Paper
The work reported here concerns induction of an adaptive response by low doses of quercetin to challenging doses of quercetin and other compounds, namely hydrogen peroxide and mitomycin C , using induction of chromosomal aberrations in V79 cells as the end point.
Mutagenesis  •  1997  |  View Paper
Our findings suggest that quercetin may result in genomic instability in the tested dose range and significant reduction in MMC induced genotoxicity in the highest dose tested.
Pre-treatment with quercetin significantly reduced the frequency of mitomycin C (MMC) induced MN as well as CA, but no clear correlation between the dose and effect could be observed.
Mutation research  •  2011  |  View Paper