Possible Interaction: Mitomycin and Quercetin

“Concentrations of 0.03, 0.15, 0.3, 0.6, 1.5 and 3mM quercetin significantly reduced the DNA strand breakage induced by mitomycin C (P<0.001) but the highest concentration of 6mM quercetin did not show a protective effect.”

“Thus, in human lymphocytes quercetin and rutin displayed protective effects on DNA damage induced by mitomycin C , in a concentration-dependent manner.”

“Quercetin was found to be also an effective protector … damage induced by mitomycin C. CONCLUSION We conclude that quercetin , one of the most abundant flavonoids in the human diet, is highly … in reducing the DNA damage caused by the antitumor agents, idarubicin and mitomycin C , following bioactivation … P450 reductase.”

“The work reported here concerns induction of an adaptive response by low doses of quercetin to challenging doses of quercetin and other compounds, namely hydrogen peroxide and mitomycin C , using induction of chromosomal aberrations in V79 cells as the end point.”

“Our findings suggest that quercetin may result in genomic instability in the tested dose range and significant reduction in MMC induced genotoxicity in the highest dose tested.”

“Pre-treatment with quercetin significantly reduced the frequency of mitomycin C (MMC) induced MN as well as CA, but no clear correlation between the dose and effect could be observed.”