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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Mitomycin
supplement:
Glutathione
Research Papers that Mention the Interaction
“Moreover, elevating cellular GSH levels also resulted in nearly proportional increases in cellular ITC uptake.”
Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates.“Cellular accumulation of each ITC was accompanied by a profound reduction in cellular GSH levels.”
“…,glutathione plays a role in the detoxification and repair of cellular injury by such diverse agents as mechlorethamine, …, cyclophosphamide, nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including Adriamycin, daunorubicin, and mitomycin C ), the sesquiterpene lactones (such as vernolepin), … other sulfhydryl-reactive diterpenes (like jatrophone).”
“Moreover, BITC and PEITC increased ROS generation and caused GSH depletion.”
“Treatment of MMC caused a significant decrease in GSH contents in SCLC cells, which was followed by increase in the formation of reactive oxygen species.”
“Cytotoxicity of continuous (at least 12-h) MMC treatment can be modestly enhanced by GSH depletion, which must precede MMC exposure in order to be effective.”
“Lowering GSH levels to less than 3% of control using buthionine sulfoximine (BSO) did … MMC given for 1 h or continuously for less than 12 h. However, GSH depletion … MMC given continuously for at least 12 h, with a dose-…% survival of 1.4 for a 24-h treatment.”
“ Mitomycin C was minimally potentiated by GSH depletion.”
“The most striking effects were a decrease of GSH in midgut tissue and hemolymph due to losses by conjugation to ITC during detoxification, and a decline of the GSH biosynthetic precursor cysteine.”
A mode of action of glucosinolate-derived isothiocyanates: Detoxification depletes glutathione and cysteine levels with ramifications on protein metabolism in Spodoptera littoralis.“MMC-induced SCEs and cell cycle delay significantly with respect to control and the frequency of SCEs was increased considerably while MMC treatment combined with either GSH or BSO.”
“The induction of cell cycle delay by MMC was reduced significantly when GSH or BSO was present along with MMC.”
“As another effect, GSH accelerates the rate of reduction of MC by "slow" reducing agents such as cytochrome c reductases and H2/PtO2.”
“The conjugation of GSH with activated MC is likely to represent detoxication in mammalian cells.”
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