“At both doses of 7.5 and 10 mg/kg of MMC, decrease in body weight of mice after intraperitoneal administration of MMC were suppressed by increasing the concentration of gelatin.”
“These results suggested that the enhancement of antitumor effect of MMC by the gelatin viscous solution could be caused by decrease in the clearance rate of MMC from the peritoneal cavity to systemic circulation due to decreasing its diffusivity in gelatin matrix.”