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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mitomycin
supplement:
Flavone Acetic Acid
Research Papers that Mention the Interaction
“After FAA transduction of mutant progenitor cells, either colony number or colony size increased in the presence of MMC.”
Functional correction of Fanconi anemia group A hematopoietic cells by retroviral gene transfer.“We have reported enhancement of the combined antitumor effects of MMC plus FAA and hyperthermia (HT).”
Potentiation of the cytotoxicity of carboquone by flavone acetic acid combined with hyperthermia“Antitumor response obtained in animals treated with FAA plus MMC with HT was clearly better than that obtained in any of the other groups.”
“In the present study, we investigated whether FAA could increase the cytotoxicity of mitomycin C (MMC), a bioreductive drug with selective cytotoxicity against hypoxic cells, under either normothermic or hyperthermic conditions.”
“We used B 16 melanoma cells both in vitro and in vivo to determine whether Flavone acetic acid (FAA) can increase the cytotoxicity of mitomycin C (MMC) under normothermic and hyperthermic (HT) conditions.”
“Since the microenvironmental consequences of induced ischaemia are reductions in both oxygenation and pH these parameters are probably responsible in large part for the enhancement of cytotoxicity observed when MMC and FAA are combined.”
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