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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mitomycin
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Precis: The use of mitomycin-C as a mixed formulation with lidocaine and epinephrine for filtration surgery may alter its pH and consequently affect clinical effectivity.”
pH of Mitomycin-C Formulations for Filtration Surgery“When beta-adrenergic stimulants such as isoproterenol, epinephrine , terbutaline and turobuterol were added at concentrations over 10(-14) M 15 to 60 min before mitomycin C, the colony-forming ability of HeLa cells was significantly inhibited more than by mitomycin C alone.”
“Among several sympathomimetic drugs, isoproterenol, epinephrine and norepinephrine significantly potentiated the cytotoxic effect and the uptake of MMC into rat ascites hepatoma AH130 cells in in vitro experiments, but salbutamol, tulobuterol and phenylephrine did not.”
Enhancement of the cytotoxic effect of mitomycin C by beta-adrenergic stimulants in rat ascites hepatoma AH130 cells.
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