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Last Updated: 2 years ago

Possible Interaction: Mitomycin and Caffeine



Research Papers that Mention the Interaction

For a variety of pharmaceutical agents (acetazolamide, mitomycin C , hydroxyurea, 5-fluorouracil), caffeine was shown to enhance the teratogenic effect of the agent.
Regulatory toxicology and pharmacology : RTP  •  1994  |  View Paper
The combined treatment of mice with caffeine (3 x 100 mg/kg) and MMC or CP caused an up to 45-49% potentiation of clastogenesis in the bone marrow of male, female and pregnant female C57Bl and BDF1 mice but not in fetal mouse livers.
Mutation research  •  1991  |  View Paper
Nevertheless, both caffeine and SB218078 enhanced the genotoxic effect of MMC in a long-term clonogenic assay.
Cell cycle  •  2006  |  View Paper
Furthermore, caffeine also inhibited the accumulation of p53 by a variety of stress-inducing agents in vivo, such as 5-fluorouracil, doxorubicin, mitomycin C , camptothecin and roscovitine.
Carcinogenesis  •  2003  |  View Paper
This synergistic effect of caffeine was also observed with cyclophosphamide (44.8%), mitomycin C (44.8%) and adriamycin (27.8%).
Japanese journal of cancer research : Gann  •  1989  |  View Paper
Caffeine showed a marked synergistic effect on sarcoma cells with the DNA-damaging agents, ADR, CDDP, CPM and MMC in terms of colony inhibition.
Gan to kagaku ryoho. Cancer & chemotherapy  •  1987  |  View Paper
In human lymphocytes, when caffeine was added during the S phase under conditions of concurrent exposure to MMC , both SCEs and homologous exchanges increased.
Basic life sciences  •  1984  |  View Paper
The frequency of interchromatic exchanges induced by mitomycin C in cultured human lymphocytes was markedly lowered in the presence of caffeine or isonicotinic acid hydrazide (INH) during a post-treatment period.
Mutation research  •  1981  |  View Paper
The survival of FA cells was enhanced significantly when 0.5 mM caffeine or 0.5 mM adenine was added for 72 h after the cells were exposed to MMC.
Mutation research  •  1981  |  View Paper
The combination of MC and CAF caused a remarkable increase in all types of chromosome aberrations, but the most startling effect was the appearance of many cells with multiple aberrations (shattered chromosomes).
Mutation research  •  1979  |  View Paper
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