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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Mitomycin and Ascorbate



Research Papers that Mention the Interaction

As ascorbic acid is a reducing agent that is known to be able to reduce quinones, it could be possible that the observed modulatory effects are a consequence of a direct redox reduction between mitomycin C and ascorbate.
As the … of mitomycin C … ascorbate is rather inefficiently at physiologically relevant pH values we conclude that the modulatory effect of ascorbate on the cytotoxicity of mitomycin C is not the result of a direct redox reaction and therefore this modulation must be the consequence of other biochemical mechanisms.
Bioorganic chemistry  •  2013  |  View Paper
Furthermore, ascorbate increased the toxic potencies of both BMY 25282 and MMC in catalase-inactivated hepatocytes by as much as 60- and 40-fold, respectively.
Biochemical pharmacology  •  1993  |  View Paper