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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Mitomycin and Antioxidants

supplement:

Antioxidants

Research Papers that Mention the Interaction

BITC reduced the phosphorylation of protein kinase B (AKT/PKB) and FOXO1; promoted FOXO1 translocation from cytoplasm into the nucleus antagonizing the insulin effect; was able to down-regulate the gene and protein expression of gluconeogenic enzymes; and induced the gene expression of antioxidant and detoxification enzymes.
PloS one  •  2016  |  View Paper
Viability loss in cells exposed to MMC was decreased by inhibitors of caspase-3, -8 and -9 and attenuated by antioxidants (N-acetylcysteine, dithiothreitol, ascorbate and rutin).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Using E.coli bacteria (AB 1157) and leukemia cells (HL 60) as a model for in vitro studies it was established that the efficiency of mitomycin C (MMC) can be influenced in the presence of antioxidant vitamins.
Anticancer research  •  1999  |  View Paper
Finally, MMC exposure induced oxidative stress by altering the antioxidant status of the liver and downregulating the mRNA expression of superoxide dismutase, glutathione peroxidase, and glutathione S-reductase.
Environmental Science and Pollution Research  •  2021  |  View Paper