Possible Interaction: Mitoguazone and S-Adenosylmethionine

“The decarboxylation of SAM is inhibited by the toxic cytostatic drug methylglyoxalbis-(guanylhydrazone ) (MGBG).”

“Inhibition of the synthesis and decarboxylation of SAM by cycloleucine and methylglyoxal bis(guanylhydrazone) ( MGBG ), respectively, did not cause the expected pattern of changes, i.e. decreases of both SAM and SAH in the former case and either increase or no change in both parameters in the latter.”

“Instead, both cycloleucine and MGBG increased SAH while decreasing SAM , suggesting an involvement of other properties of these drugs.”

“Despite the fact that MGBG treatment caused a slight increase in intracellular levels of AdoMet , it is unlikely that this elevation will increase the amount of intracellular methylation.”

“Intracellular levels of these naturally occurring polycations were manipulated in certain situations by treating whole cells with methylglyoxal bis-(guanylhydrazone ), an inhibitor of the S-adenosyl-L-methionine decarboxylases.”

“… S-adenosylmethionine content was reduced … by treatment with methylglyoxal bis(guanylhydrazone ), a potent reversible inhibitor of S-adenosylmethionine decarboxylase, but had returned to control levels by 24 h. The related …-aminoguanidine), reduced levels slightly less to about 20% of control, but maintained them at this value for 2 days.”

“Here we demonstrate that partially purified aminopropyltr~sfera~s from … were strongly inhibited by SAM and that administration of SAM in … methylglyoxal bis(guanylhydrazone) (MGBG) caused a decrease in the concentration not only of spermid~e, but … of sper~e in the liver and kidney of partially hepatectomized rats.”

“The amount of S-adenosyl-l-methionine decarboxylase present in rat liver was enhanced 17-fold by administration of methylglyoxal bis(guanylhydrazone ),* a specific inhibitor of the enzyme.”