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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Mitoguazone and S-Adenosylmethionine

Research Papers that Mention the Interaction

The decarboxylation of SAM is inhibited by the toxic cytostatic drug methylglyoxalbis-(guanylhydrazone ) (MGBG).
Cancer letters  •  1988  |  View Paper
Inhibition of the synthesis and decarboxylation of SAM by cycloleucine and methylglyoxal bis(guanylhydrazone) ( MGBG ), respectively, did not cause the expected pattern of changes, i.e. decreases of both SAM and SAH in the former case and either increase or no change in both parameters in the latter.
Instead, both cycloleucine and MGBG increased SAH while decreasing SAM , suggesting an involvement of other properties of these drugs.
Biochemical pharmacology  •  1987  |  View Paper
Despite the fact that MGBG treatment caused a slight increase in intracellular levels of AdoMet , it is unlikely that this elevation will increase the amount of intracellular methylation.
European journal of cancer & clinical oncology  •  1984  |  View Paper
Intracellular levels of these naturally occurring polycations were manipulated in certain situations by treating whole cells with methylglyoxal bis-(guanylhydrazone ), an inhibitor of the S-adenosyl-L-methionine decarboxylases.
Radiation research  •  1983  |  View Paper
S-adenosylmethionine content was reduced … by treatment with methylglyoxal bis(guanylhydrazone ), a potent reversible inhibitor of S-adenosylmethionine decarboxylase, but had returned to control levels by 24 h. The related …-aminoguanidine), reduced levels slightly less to about 20% of control, but maintained them at this value for 2 days.
The Journal of biological chemistry  •  1980  |  View Paper
Here we demonstrate that partially purified aminopropyltr~sfera~s from … were strongly inhibited by SAM and that administration of SAM in … methylglyoxal bis(guanylhydrazone) (MGBG) caused a decrease in the concentration not only of spermid~e, but … of sper~e in the liver and kidney of partially hepatectomized rats.
FEBS letters  •  1980  |  View Paper
The amount of S-adenosyl-l-methionine decarboxylase present in rat liver was enhanced 17-fold by administration of methylglyoxal bis(guanylhydrazone ),* a specific inhibitor of the enzyme.
The Biochemical journal  •  1974  |  View Paper