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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mitoguazone
supplement:
Long Chain Fatty Acid
Research Papers that Mention the Interaction
“The bis(guanylhydrazones ) likewise inhibit carnitine-dependent mitochondrial oxidation of long-chain fatty acids , competitively in respect to carnitine.”
S-adenosylmethionine decarboxylase as target of chemotherapy.“We previously found that the anti-cancer drug methylglyoxal bis(guanylhydrazone ) (mitoguazone) depresses carnitine-dependent oxidation of long-chain fatty acids in cultured mouse leukaemia cells [Nikula, Alhonen-Hongisto, Seppänen & Jänne (1984) Biochem.”
Carnitine prevents the early mitochondrial damage induced by methylglyoxal bis(guanylhydrazone) in L1210 leukaemia cells.
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