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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Misonidazole
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“We conclude that vitamin B6 is not useful in preventing clinical neurotoxicity of MISO or DMM.”
The effect of vitamin B6 on the neurotoxicity and pharmacology of desmethylmisonidazole and misonidazole: clinical and laboratory studies.“A series of toxicological and pharmacological experiments was performed to test the hypothesis that alterations of pyridoxine (Vitamin B6) metabolism may play an important role in the development of misonidazole (MISO) neurotoxicity.”
“If depletion or altered metabolism of pyridoxine by reduced metabolites is … the neurotoxic effects of nitroimidazoles in humans, then concomitant administration of pyridoxine (in doses greater than the molar quantity of NH2-MISO formed) … development of such symptoms and allow administration of larger doses of MISO than are … employable.”
“Mice receiving daily intraperitoneal injections of MISO suffered significantly less toxicity (as determined by survival, weight gain and neurological tests) when large doses of pyridoxine-HCl (PYR) were delivered concomitantly, and consequently were able to tolerate administration of more than twice as many MISO injections.”
Misonidazole neurotoxicity in mice decreased by administration with pyridoxine.
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