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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Mirtazapine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Noradrenaline or serotonin (5‐HT) reuptake‐inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5‐HT2 and/or H1 receptors.”
Neuroendocrinological Mechanisms of Actions of Antidepressant Drugs“In contrast, mirtazapine significantly reduced the cortisol and ACTH concentrations during the DEX/CRH test within 1 week.”
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