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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Mirtazapine and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Noradrenaline or serotonin (5‐HT) reuptake‐inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5‐HT2 and/or H1 receptors.
Journal of neuroendocrinology  •  2007  |  View Paper
In contrast, mirtazapine significantly reduced the cortisol and ACTH concentrations during the DEX/CRH test within 1 week.
Psychopharmacology  •  2006  |  View Paper