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Discover Supplement-Drug Interactions

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Last Updated: 10 months ago

Possible Interaction: Minoxidil and Tretinoin



Research Papers that Mention the Interaction

The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.
Journal of the American Academy of Dermatology  •  1986  |  View Paper
Tretinoin is a mitogen by itself and also enhances the absorption of minoxidil which acts by enlarging the miniaturized hair follicles.
International journal of dermatology  •  2009  |  View Paper
For this reason, it was assumed that tretinoin would be helpful in alleviating the inconvenience associated with the recommended twice-daily application of minoxidil.
Tretinoin is known to increase the percutaneous absorption of minoxidil and, therefore, to enhance the response of AGA to minoxidil.
American journal of clinical dermatology  •  2007  |  View Paper
All-trans retinoic acid (ATRA) has been reported to act synergistically with minoxidil in vivo: they can enhance more dense hair regrowth than either compound alone.
In addition, minoxidil plus ATRA elevated phosphorylated Erk, phosphorylated Akt and the ratio of Bcl-2/Bax, but decreased the expressions of P53 and P21 more effectively than by minoxidil alone.
Minoxidil plus ATRA additively promoted hair growth in vitro, compared with minoxidil alone.
minoxidil … ATRA would additively enhance hair growth by mediating dual functions: 1) the prolongation of cell survival by activating the Erk and Akt signaling pathways, and … of apoptosis of DPCs and epithelial cells by increasing the ratio of Bcl-2/Bax and downregulating the expressions of P53 and P21.
Journal of Korean medical science  •  2007  |  View Paper
We propose that certain retinoids increase the rate of hair growth, prolong the anagen phase of the hair cycle, play a role in converting vellus to terminal hairs, and act synergistically with minoxidil to produce more dense hair regrowth from regressing follicles than either compound alone.
Clinics in dermatology  •  1988  |  View Paper
Another drug Tretinoin (TRET) is known for its comedolytic activity and is reported to enhance percutaneous absorption of MXD.
Cutaneous and ocular toxicology  •  2019  |  View Paper