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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Minocycline
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Severe dose-dependent suppression of DNA synthesis was found in the presence of two preparations of minocycline , oxytetracycline, and the ascorbic acid salt of tetracycline.”
The effect of antibiotics on cell-mediated immunity.“Studies suggest that the concomitant use of vitamin C may help prevent adult-onset pigmentation caused by minocycline.”
“The literature shows that possible preventive efforts revolve around cessation of the drug or the use of large doses of vitamin C or other antioxidants in conjunction with minocycline therapy to prevent the formation of the pigment responsible for the staining.”
“In a case infected with MRSA, of which the Minocycline-therapy had been ineffective, the combined administration of Vitamin C with Minocycline led him successfully to the negativeness of MRSA.”
“NDMA formation from minocycline and dodxycycline was blocked by ascorbic acid.”
“Dimethylnitrosamine formation from minocycline and doxycycline was blocked by ascorbic acid.”
[On the problem of dimethylnitrosamine formation from tetracycline-derivatives by nitrosation reaction in acidic medium (author's transl)].
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