Possible Interaction: Minocycline and Tretinoin

“Here, we hypothesized that minocycline may directly affect RA homeostasis in the CNS via altering local RA degradation.”

“We revealed that minocycline potently blocks RA degradation as measured by reversed-phase high-performance liquid chromatography and in a viable RA reporter cell line, even at low micromolar levels of minocycline.”

“Interestingly, minocycline potently blocked RA degradation in rat skin microsomes, and strikingly enhanced RA levels in RA‐synthesizing cell cultures, in a dose‐dependent manner.”

“While pro-inflammatory stimulation with lipopolysaccharides resulted in increased tryptophane-degrading indoleamine-2,3-dioxygenase IDO-expression and TNF-α levels in primary human monocyte-derived microglial-like cells, this effect was attenuated by minocycline only in the presence of retinoids.”

“Therefore, we hypothesized minocycline to putatively interact with intracellular RA homeostasis in PCA.”

“We review the literature on the pathogenesis, clinical features, and treatment of postradiation acne, and discuss rapid resolution of a radiation-induced acneform eruption after combination treatment with tretinoin and minocycline.”

“The inference of an independent causal role of these retinoids is further cautioned by the fact that six patients were concurrently using tetracycline or minocycline.”