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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Minocycline
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and ischemic stroke.”
Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats“ Minocycline treatment reduced brain iron accumulation, T2* lesion volume, iron-handling protein upregulation, neuronal cell death, and neurological deficits (P<0.05).”
“CONCLUSIONS Iron plays a critical role in WMI after ICH, which can be suppressed by minocycline through reducing the damage induced by Fe.”
“The co-injection of minocycline with iron significantly reduced iron-induced brain swelling (n = 5, p < 0.01).”
“Intracaudate injection of iron caused brain edema, blood–brain barrier leakage, and brain cell death, all of which were significantly reduced by coinjection with minocycline.”
“Oxidation of isolated culture membranes by iron was also inhibited by minocycline.”
“Results: Our data revealed that the systemic administration of DFX and/or minocycline decreased iron accumulation.”
The combination of deferoxamine and minocycline strengthens neuroprotective effect on acute intracerebral hemorrhage in rats“Additionally, MH can directly inhibit calcium influx through the N-methyl-D-aspartate (NMDA) receptors, mitochondrial calcium uptake, poly(ADP-ribose) polymerase-1 (PARP-1) enzymatic activity, and iron toxicity.”
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