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Last Updated: 2 years ago
drug:
Milrinone
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Currently available inotropes, such as dobutamine and milrinone , increase cardiac contractility at the expense of increased intracellular concentrations of calcium and cAMP, contributing to increased heart rate, hypotension, arrhythmias, and mortality.”
A novel approach to improve cardiac performance: cardiac myosin activators“In isolated rabbit cardiomyocytes, milrinone (>10 μM) caused greater elevations in intracellular cAMP and calcium than cilostazol.”
“A submaximal, but not a maximal, inotropic effect of ouabain could be increased by the addition of milrinone; in contrast, both ouabain and calcium increased the maximal inotropic effect of milrinone by 1.7±0.2 mN and 2.7±0.3 mN, respectively.”
“Aim: Milrinone , a phosphodiesterase III inhibitor, exerts positive inotropic effects which induce an increase in the intracellular calcium concentration by raising the cyclic adenosine monophosphate level in cardiac muscle.”
“Digoxin (10(-6) mol/L) and milrinone (10(-5) mol/L) increased LV contractility with a concomitant increase in Ca2+ transient, and the relative increase of Ca2+ transient produced by milrinone was much more than that by digoxin.”
Changes in calcium transient and left ventricular function during positive inotropic stimulation and myocardial ischemia in indo-1-loaded beating guinea pig heart.“It is concluded that milrinone inhibits vascular smooth muscle contractility by probably acting at multiple sites to decrease the availability of intracellular free Ca required for activation.”
“These data suggest that the diminished inotropic effect of milrinone in the fetus may be due, at least in part, to the decreased inotropism of cyclic AMP and calcium.”
“The effects of milrinone were studied in ferret papillary muscle stimulated at various rates and temperatures from 23° to 36° C. In voltage-clamp experiments, 50 μg/ml (0.237 mM) milrinone induced a 2.1-fold increase in calcium current at 28° or 36°C.”
“In conclusion, milrinone and its analogue amrinone appear to increase the entry of calcium into myocardial cells, primarily by increasing the influx of this cation during the slow inward calcium current.”
“Preliminary findings indicate, however, that milrinone may play a role in initiating an earlier spontaneous release of Ca++ from the sarcoplasmic reticulum.”
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